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Xu, Peisheng
Peisheng Xu
Assistant Professor
Office Location
USC Campus

715 Sumter St

, SC29208
Phone: (803) 777-0075

Fax: 803-777-8356
Home Page / Laboratory Page
Direct Link to Profile
  • Purdue University, Postdoctoral Research Associate 2007-2009 (Pharmaceutics)
  • University of Wyoming, Ph.D. 2007 (Chemical Engineering)
  • Beijing University of Chemical Technology, M.S. (Chemical Engineering)
  • Nanchang University, B.S. (Chemical Engineering)
The primary interests of our lab are design and synthesis biomaterials, and exploring their biomedical applications. The long-term goals of our research are to develop cancer targeted nano-sized drug carrier to eradicate cancer and to design novel drug formulation to alleviate central nervous system (CNS) diseases. Currently, our foci are rational design, and synthesis of environment responsive polymers, and fabricating them into cancer or CNS targeted nanoparticle for chemotherapy or gene therapy.
  • Shen, Y., Zhou, Z., Sui, M., Tang, J., Xu, P., Van Kirk, E.A., Murdoch, W.J., Fan, M., and Radosz, M. Charge-reversal polyamidoamine dendrimer for cascade nuclear drug delivery. Nanomedicine, (2010), 5(8), 1205-1217.
  • Xu, P., Bajaj, G., Shugg, T., Van Alstine, W., and Yeo, Y.: Zwitterionic chitosan derivatives for pH-sensitive stealth coating. Biomacromolecules. (2010), 11(9), 2352-2358.
  • Ma H., Jones K.R., Guo R., Xu P., Shen Y., and Ren J., Cisplatin compromises myocardial contractile function and mitochondrial ultrastructure: Role of endoplasmic reticulum stress. Clin Exp Pharmacol Physiol. (2010) 37(4), 460-465
  • Xu, P. Quick G. and Yeo, Y., Gene delivery through the use of a hyaluronate-associated intracellularly degradable cross-linked polyethyleneimine. Biomaterials (2009) 30(29), 5834-43.
  • Ma, H., Li, S., Xu, P., Babcock, S.A., Dolence, E.K., Brownlee, M., Li, J., and Ren, J., Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) upregulation contribute to the onset of diabetic cardiomyopathy. Journal of Cellular and Molecular Medicine (2009) 13(8b), 1751-64
  • Xu, P., Gullotti, E., Tong, L., Highley, C.B., Errabelli, D.R., Hasan, T., Cheng, J.,   Kohane, D.S., and Yeo, Y., Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Molecular Pharmaceutics (2009), 6(1), 190-201.
  • Yang, Y., Bajaj, N., Xu, P., Ohn, K., Tsifansky, M., and Yeo, Y.Development of highly porous large PLGA microparticles for sustained local drug delivery to the lung. Biomaterials (2009), 30(10), 1947-53.
  • Xu, P., Li, S., Li, Q., Van Kirk, E.A, Ren, J., Murdoch, W.J., Zhang, Z., Radosz, M., and Shen, Y., Virion-mimicking nanocapsules from pH-controlled hierarchical self-assembly for gene delivery. Angewandte Chemie International Edition (2008), 47(7), 1260-1264.
  • Shen, Y., Zhan, Y., Tang J., Xu P., Johnson P.A., Radosz M., Van Kirk E.A., Murdoch, W.J. Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer drug delivery. AIChE Journal (2008), 54 (11), 2979-2989.
  • Turdi, S., Xu, P., Li, Q., Kerram, P., Shen, Y., and Ren, J., Amidization of doxorubicin alleviates doxorubicininduced cardiomyopathy. Toxicology letters (2008), 178(3), 197-201
  • Xu, P., Van, Kirk E.A., Zhan, Y., Murdoch, W.J., Radosz, M., and Shen, Y., Targeted charge-reversal nanoparticles for nuclear drug delivery. Angewandte Chemie International Edition (2007), 46(26), 4999-5002.
  • Jin, W., Xu, P., Zhan, Y., Shen, Y., Van Kirk, E.A., Alexander, B., Murdoch, W.J., Liu, L., and Issak, D.D., Degradable cisplatin-releasing core-shell nanogels from zwitterionic poly(beta-aminoester)-graft-PEG for cancer chemotherapy. Drug Delivery. (2007), 14(5), 279-86.
  • Xu, P., Li, S., Li, Q., Ren, J., Van Kirk, E.A., Murdoch, W.J., Radosz, M., and Shen, Y., Biodegradable cationic polyester as an efficient carrier for gene delivery to neonatal cardiomyocytes. Biotechnology & Bioengineering (2006), 95(5), 893-903.
  • Xu, P., Van Kirk, Edward E.A., Murdoch, W.J., Zhan, Y., Isaak, Dale D., Radosz, M., and Shen, Y., Anticancer efficacies of cisplatin-releasing pH-responsive nanoparticles. Biomacromolecules (2006), 7(3), 829-835. (Selected as one of the four “the Most Intriguing work” by CAS scientists for 2Q of 2006 from over 200,000 documents per quarter, including articles from nearly 9,500 journals, and patents from 50 active patent-issuing authorities from around the world )
  • Xu, P., Van Kirk, E.A., Li, S., Murdoch, W.J., Ren, J., Hussain, M.D., Radosz, M., and Shen, Y., Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy. Colloids and Surfaces, B: Biointerfaces (2006), 48(1), 50-57.
  • Xu, P., Tang, H., Li, S., Ren, J., Van Kirk, E.A., Murdoch, W.J., Radosz, M., and Shen, Y., Enhanced stability of core-surface cross-linked micelles fabricated from amphiphilic brush copolymers. Biomacromolecules (2004), 5(5), 1736-1744.