Patrick M. Woster, Ph.D.

SmartState Endowed Chair in Drug Discovery

Interim Chair/ Professor, Drug Discovery and Biomedical Sciences

843.876.2453 :: Charleston - 843.876.2353 :: Fax

woster@musc.edu

Dr. Patrick Woster

Biography

Patrick M. Woster is Professor of Drug Discovery and Biomedical Sciences at the South Carolina College of Pharmacy in Charleston, SC, and serves as the South Carolina SmartState™ Endowed Chair in Drug Discovery at the Medical University of South Carolina. He received a B.S. in Pharmacy from the University of Nebraska Medical Center in 1978, and a Ph.D. in Medicinal Chemistry from the University of Nebraska - Lincoln in 1986. Following postdoctoral work in chemistry at Rensselaer Polytechnic Institute (1986), and in medicinal chemistry at the University of Michigan (1987), he joined the faculty at Wayne State University in 1988.

At Wayne State, Professor Woster taught undergraduate biochemistry and medicinal chemistry courses, graduate level courses in medicinal and bioorganic chemistry, and developed a series of web-based tutorials for students in medicinal chemistry.

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Woster Pubmed

 

Education

Bachelor of Science, Pharmacy, 1978
University of Nebraska Medical Center

Doctor of Philosophy, Medicinal Chemistry, 1986
University of Nebraska 

Postdoctoral Associate, Chemistry 1986
Rensselaer Polytechnical Institute

Postdoctoral Associate, Medicinal Chemistry, 1987
University of Michigan

 

 

Consulting:

Consultant, Oridigm Pharmaceutical Co., Seattle, WA, 1996 to 2000. 
Consultant, S’Lil Biomedical Corporation, Madison, WI, 2001 - 2006.
Consultant, Cellgate, Inc., Redwood City, CA, 2006 - 2007.
Consultant, Progen Pharmaceuticals, Brisbane, Queensland, Australia, December, 2007 to present.
Consultant, Senex Biotechnology, Inc., September, 2011 to present.
Expert Witness, United States v. Moccia, Boston, MA, May, 2001.
Expert Witness, United States v. Ivanov, Boston, MA, March, 2002.

 

 

Laboratory

Drug Discovery Building
Room 405, MSC 140
70 President St., Charleston, SC 29425


Laboratory: DD422 and DD427
Lab Phone: 843-876-2454

Appointment History

Current

Professor and South Carolina SmartState™ Endowed Chair (March 2011 to present), Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425

Past appointments

  • Professor (August, 2001 - present) - Dept. of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48202. 
  • Associate Professor (September, 1995 to August, 2001) - Dept. of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48202. 
  • Assistant Professor (July 1989 to August, 1995) - Dept. of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48202. 
  • Lecturer (Jan. 1988 to June 1989) - Dept. of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48202

 

Bio Continued....

In 2011, Professor Woster moved to MUSC, where he was appointed Professor and South Carolina SmartState™ Endowed Chair in Drug Discovery. Professor Woster maintains an active research program that has been funded by several agencies, including the National Institutes of Health, the World Health Association and the pharmaceutical industry. Ongoing projects in the Woster laboratories include the synthesis of alkylpolyamines as antitumor or antiparasitic agents, synthesis of novel inhibitors of lysine-specific demethylase 1 and histone deacetylase as epigenetic modulators, solution- and solid-phase synthesis of peptide-based inhibitors of plasmepsin, synthesis of S-adenosylmethionine analogues as mechanism-based enzyme inhibitors and synthesis of furanocoumarins as inhibitors of cytochrome P450. Dr. Woster has directed a number of Ph.D. dissertations and Master's theses, and has mentored ten postdoctoral associates. To date, he has authored more than 95 articles in peer-reviewed research journals, and more than 100 research abstracts and invited presentations. Dr. Woster has also served as a member of two NIH study sections, and on editorial boards or as a reviewer for numerous scientific journals.

Professor Woster has been a member of ACS and the Division of Medicinal Chemistry since 1979, and is also a member of the Organic Chemistry and Biological Chemistry divisions. He assumed an active service role in the Division of Medicinal Chemistry in 1994 as a member of the Membership Committee and Chair of the Electronic Communications Committee. Dr. Woster was a member of the Division Long Range Planning Committee (1998 - 2000), and organized 4 symposia for National ACS meetings. He served as Secretary and Public Relations Chair for the Division of Medicinal Chemistry from 1994 - 2010, and is currently Chair of the Division. Dr. Woster has served as an officer for the American Association of Colleges of Pharmacy (AACP), where he is a Past Chair of the Section of Teachers of Chemistry. During 2004-2005, he was a member of the AACP Executive Board of Directors, and Chair of the Academic Sections Coordinating Committee.

Professional Societies:

  • Member of the Graduate Faculty, Wayne State University, 1988 to 2011
  • Member of the Graduate Faculty, Medical University of South Carolina, 2011 to present.
  • Member, Barbara Ann Karmanos Cancer Center, Developmental Therapeutics Section, Detroit, MI, 1994 to 2011
  • Member, Hollings Cancer Center, Developmental Cancer Therapeutics program, Medical University of South Carolina, 2011 to present.
  • Faculty Advisor, Alpha Chi Chapter of the Rho Chi Society, Wayne State University, 1995 to 1998. Member, American Chemical Society.

ACS Division of Medicinal Chemistry:   
Division of Medicinal Chemistry Membership Committee, 1994-1996.
Division of Medicinal Chemistry Electronic Media Committee, 1994-2000. Member, Long Range Planning Committee, 1998 - 2000.
Division Secretary and Public Relations Chair, 1994 to 2010.
Division Vice-Chair and Chair of the Long Range Planning Committee, 2011
ivision Chair, 2012

  • Member, ACS Division of Organic Chemistry.
  • Member, ACS Division of Biological Chemistry.
  • Member, American Association of Colleges of Pharmacy, 1988-2006.

Appointed to Joint Council of Deans/Council of Faculties Committee on Eliminating the Barriers to the Development and Implementation of Effective Teaching, December, 1994.
Chemistry Section Communications Committee, 1995 to present (Chair, 1995-1996).
Chemistry Section Ad Hoc Pharm.D./Ph.D. Committee 1996-97
Secretary, Section of Teachers of Chemistry, 2000-2002.
Member, AACP Academic Affairs Committee, 2000-2001
Chair-Elect, Section of Teachers of Chemistry, 2002-2003
Chair, Section of Teachers of Chemistry, 2003-2004
Member, 2003-04 AACP Academic Sections Coordinating Committee
Chair, 2004-05 AACP Academic Sections Coordinating Committee
Member, 2004-05 AACP Executive Board of Directors

  • Member, American Association for the Advancement of Science, 1988 to present.
  • Member, American Association of Pharmaceutical Scientists, 2009 to present.
  • Member, American Association of Cancer Research, 2011 to present.

Scientific Review Panels:

 

Reviewer, National Science Foundation, Division of Metabolic Biochemistry, 1996. 
External Evaluator, doctoral dissertation of Laurence Covassin, Ph.D., University of Laval, Quebec City, Quebec, August, 2000.
Expert Panel Member, Novartis Foundation Discussion Meeting, “Drugs for Developing World Diseases: Translating New Molecular Targets into Candidates for Development”, November 3, 2003, London, UK.
Reviewer, Philip Morris External Research Grant Program, 2003.
Member, National Institutes of Health, NIAID Tropical Disease Research Unit Special Emphasis Grant Review Panel, December 15-17, 2003, in Bethesda, MD.
Member, National Institutes of Health, NCI Program Project Grant Review Panel, October 24-27, 2004, in Bethesda, MD.
Member, Scientific Advisory Committee, 18th International Symposium on Medicinal Chemistry, held August 15-19, 2004, in Copenhagen, Denmark. 
Member, National Institutes of Health, Rapid Access to Intervention Development (RAID) Review Panel, October, 2005.
Member, National Institutes of Health, Rapid Access to Intervention Development (RAID) Review Panel, October, 2006. 
Reviewer, American Chemical Society, Petroleum Research Fund Grant Program, 1994 - 2005.
Member, Scientific Advisory Committee, 19th International Symposium on Medicinal Chemistry, held September 2-6, 2006, in Istanbul, Turkey.
Member, Canadian Institutes for Health Research Drug Development Initiative Grant Review Panel, January 11-12, 2006, in Ottawa, Ontario, CANADA. 
Member, Canadian Institutes for Health Research Drug Development Initiative Grant Review Panel, January 10-11, 2007, in Ottawa, Ontario, CANADA.
Reviewer, The Wellcome Trust Grant Programme, 2007.
Rho Chi – Schering Plough - AFPE First Year Graduate Scholarship Review Panel, 2005 to present.
Member, National Institutes of Health, Special Emphasis Panel (SEP) for R13 Conference Grants Review, November, 2010, 2012.
Member. International Advisory Committee, International Symposium For Chinese Medicinal Chemists (ISCMC-8) and International Symposium on Biomolecular Chemistry (ISBOC-9). 

Awards and Honors

  • Member, Rho Chi Pharmaceutical Honor Society Member, Sigma Xi Research Honor Society Member, Golden Key Honor Society 
  • Teacher of the Year, Wayne State University College of Pharmacy and Health Sciences, 1988.
  • Teacher of the Year, Wayne State University College of Pharmacy and Health Sciences, 1989. 
  • Teacher of the Year, Wayne State University College of Pharmacy and Health Sciences, 1990. 
  • Teacher of the Year, Wayne State University College of Pharmacy and Health Sciences, 1991. 
  • Teacher of the Year, Wayne State University College of Pharmacy and Health Sciences, 1992 
  • Wayne State University President's Award for Excellence in Teaching, 1993. 
  • Teacher of the Year, Wayne State University College of Pharmacy and Health Sciences, 1994. 
  • Teacher of the Year, Wayne State University College of Pharmacy and Health Sciences, 1996. 
  • Teacher of the Year, Wayne State University College of Pharmacy and Health Sciences, 1997. 
  • Eugene Applebaum College of Pharmacy and Health Sciences Teaching Excellence Award, 1998. 
  • Eugene Applebaum College of Pharmacy and Health Sciences Teaching Excellence Award, 2006. 
  • American Men and Women of Science, 1992-present.
  • Recipient, Wayne State University Career Development Chair, 1998-99.
  • Chair and Organizer, 5th Biennial Symposium on Polyamines in Parasites, July 9-11, 2008. 
  • Chair, 2009 Gordon Research Conference on Polyamines.
  • Editorial Advisory Board, Burger’s Medicinal Chemistry, 7th Edition, 2007 to present.
  • Eugene Applebaum College of Pharmacy and Health Sciences Research Excellence Award, 2010. 
  • Director, MUSC Center for Drug Design and Synthesis, 2011 to present.

Professional Journal Affiliations:

 

Editorial Advisory Board, Journal of Medicinal Chemistry, 2012 to present.
Editorial Advisory Board, Burger’s Medicinal Chemistry, 7th Edition, 2007 to present.
Editorial Advisory Board, Research and Reports in Medicinal Chemistry, 2011 to present.
Associate Editor, Current Medicinal Chemistry, 1998 - 2003
Editorial Board, Current Topics in Medicinal Chemistry, 2000 - 2003
Editorial Board, Mini Reviews in Medicinal Chemistry, 2000 - 2003.
Editorial Board, Current Medicinal Chemistry - Anticancer Agents, 2000 - 2003.
Editorial Board, American Journal of Pharmaceutical Education, 2003-2007.
Pharmaceutical Chemistry Board of Expert Analysts, ChemTracts Organic Chemistry, 1997 - 2002.
Reviewer, American Journal of Pharmacy Education, 1989, 1991, 1993, 1997, 1998, 2000, 2003 - 2005.
Reviewer, Bioorganic and Medicinal Chemistry Letters, 1991 to present.
Reviewer, Bioorganic and Medicinal Chemistry, 1995 to present.
Reviewer, Cellular and Molecular Biology, 1998 to present.
Reviewer, Journal of Medicinal Chemistry, 1992 to present.
Reviewer, Medicinal Chemistry Research, 2007 to present.
Reviewer, Journal of Organic Chemistry, 2003 to present.
Reviewer, Journal of the American Chemical Society, 2004 to present.
Reviewer, Biochemical Pharmacology, 1999 to present.
Reviewer, Antimicrobial Agents and Chemotherapy, 2001 to present.
Reviewer, Organic Letters, 2001 to present.
Reviewer, Tetrahedron Letters, 2004 to present.
Reviewer, Synthesis, 2005 to present.
Reviewer, Canadian Journal of Chemistry, 2005 to present.
Reviewer, Mendeleev Communications (Royal Society of Chemistry), 2005 to present.
Reviewer, Journal of the Brazilian Society of Chemistry, 2005 to present.
Reviewer, European Journal of Medicinal Chemistry, 2005 to present.
Reviewer, Life Sciences, 2005 to present.
Reviewer, European Journal of Pharmaceutical Sciences, 2006 to present.
Reviewer, The Prostate, 2007 to present.
Reviewer, Memorias de Instituto Oswaldo Cruz, 2008 to present.
Reviewer, Cancer Research, 2008 to present.
Reviewer, Chemico-Biological Interactions, 2008 to present.
Reviewer, European Journal of Cancer, 2009 to present.
Reviewer, ACS Medicinal Chemistry Letters, 2010 to present.
Reviewer, Apoptosis, 2010 to present.
Reviewer, Nature Chemical Biology, 2010 to present.
Reviewer, Chemical Reviews, 2011 to present.
Reviewer, Cancer Letters, 2011 to present.
Reviewer, Amino Acids, 2011 to present.
Reviewer, Acta Biochimica et Biophysica Sinica, 2011 to present.
Reviewer, MedChemComm, 2011 to present

Patents:

1. Edwards, D.J. and Woster, P.M.: 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor in 
grapefruit juice.  U.S. Patent No. 6,160,006, issued December 12, 2000. 
2. Woster, P.M., Varghese, S. and Casero, Jr., R.A.: Selectively Targeted Histone Deacetylase Inhibitors. U.S. Patent No. 60/672,470 filed June 21, 2006.
3. Woster, P.M., Ward, T.R. and Casero, Jr., R.A.: Polyamines Useful as Antiparasitic and Anticancer Therapeutics, and as Lysine-Specific Demethylase Inhibitors.  U.S. Patent No. 60/707,420 filed August 9, 2006.
4. Casero, R.A., Jr.; Woster, P.M.: Lysine-Specific Demethylase Inhibitors. Provisional patent #57856-30037 filed to U.S. Patent Office, April 15, 2007.
5. Basu, H.; Church, D.R.; Woster, P.M.; Wilding, G.: N1,N4-bis(buta-1,3-dienyl)butane-1,4-diamine Compounds and Methods of Treatment Thereof. U.S. Patent No. P06243US filed May 3, 2007.
6. Oliviera, M.A.; Wortham, B.W.; Woster, P.M.; Moyer, M.P.: Method for Antimicrobial Activities Using Polyamine Analogues Against Clinically Relevant Bacteria. Provisional patent #12179-3001 filed to U.S. Patent Office, April 15, 2007.
7. Kowluru, Anjaneyulu and Woster, Patrick M.: Histone Deacetylase Inhibitors Useful in the Protection of Human Beta Cells from Nitric Oxide-Mediated Apoptosis. Provisional patent filed November 26, 2008.
8. Casero, Robert A. and Woster, Patrick M.: Isosteric analogues of (bis)guanidines and (bis)biguanides as epigenetic modulators. PCT Application #71699 submitted August 18, 2010.
9. Bytheway, I., Casero, R.A. and Woster, P.M. Small Molecule Epigenetic Modulators. Provisional patent # 61381739 filed September 10, 2010.

Selected Publications

Journal Articles (Complete list includes 100 peer-reviewed manuscripts and 97 abstracts, h-index = 26)

70. Huang, Y.; Greene, E.; Murray-Stewart, T.; Goodwin, A.C.; Baylin, S.B.; Woster, P.M.; Casero, R.A.: Inhibition of the lysine specific demethylase, LSD1, by novel polyamine analogues results in re-expression of aberrantly silenced genes. Proc. Natl. Acad. Sci. U.S.A., 2007104, 8023-8028. 
71. Wang, X.; Feith, D.J.; Welsh, P.; Coleman, C.S.; Lopez, C.; Woster, P.M.; O’Brien, T.G.; Pegg, A.E.: Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis. Carcinogenesis 200728, 2404-2411.
72. Wei, G.; DeFeo, K.; Hayes, C.S.; Woster, P.M., Mandik-Nayak, L.; Gilmour, S.K.: Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Research200868, 2214-2222.
73. Varghese, S.; Senanayake, T.; Murray-Stewart, T.; Casero, Jr., R.A.; Woster, P.M.: Polyaminohydroxamic Acids and Polyaminobenzamides as Isoform Selective Histone Deacetylase Inhibitors. J. Med. Chem200851, 2447-2456.
74. Susick, L.; Senanayake, T.; Veluthakal, R.; Woster, P.M.; Kowluru, A.: A novel histone deacetylase inhibitor prevents IL-1β-induced metabolic dysfunction in pancreatic β-cells. J. Cell. Molec. Med200810, 1-38.
75. Woster, P.M.: Antiviral agents. In “Foye’s Principles of Medicinal Chemistry – 6th Edition”, Thomas Lemke and David Williams, eds., Lippincott Williams & Wilkins, Baltimore, 2009.
76. Bacchi, C.J.; Rattendi, D.; Bi, X; Woster, P.M.: Metabolism of an alkylpolyamine analog by a polyamine oxidase from the Microsporidian Encephalitozoon cuniculi. Antimicrob. Agents Chemother.,200953, 2599-2604. 
77. Casero, Jr., R.A.; Woster, P.M.: Perspective: Recent advances in the development of polyamine analogues as antitumor agents. J. Med. Chem200952 (15), 4551-4573.
78. Ulmari. A.; Keinanen, T.A.; Karppinen, A.; Woster, P.M.; Janne, J.; Alhonen, L.: Spermine analogs regulated expression of spermidine/spermine-N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts. Biochem. J2009422, 101-109.
79. Woster, P.M.: Foreword: The ACS division of medicinal chemistry – celebrating 100 years of excellence. J. Med. Chem. 200952, 7333-7338.
80. Basu, H.S.; Thompson, T.A.; Church, D.; Clower, C.; Mehraein-Ghomi, F.; Amlong, C.A.; Martin, C.T.; Woster, P.M.; Lindstrom, M.J.; Wilding, G.: A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the TRAMP mouse model.Cancer Res2009, 69, 7689-7695.
81. Senanayake, M.D.T.; Amunugama, H.; Boncher, T.D.; Casero, Jr., R.A.; Woster, P.M.; Casero, Jr., R.A.: Design of Polyamine-Based Therapeutic Agents: New Targets and New Directions. Essays Biochem200946, 77-94.
82. Huang, Y.; Marton, L.J.; Woster, P.M.; Casero, Jr., R.A.: Polyamine analogues targeting epigenetic gene regulation. Essays Biochem2009, 46, 95-110.
83. Huang, Y.; Murray-Stewart, T.; Wu, Y.; Baylin, S.B.; Marton, L.J.; Woster, P.M. and Casero, Jr., R.A.: Novel oligoamine analogues inhibit lysine-specific demethylase 1 (LSD1) and induce re- expression of epigenetically silenced genes. Cancer Chemother. Pharmacol200915, 7217- 7228.
84. Pledgie, T.A.; Billam, M.; Hacker, A.; Sobolewski, M.; Woster, P.M.; Zhang, Z.; Casero, Jr., R.A.; Davidson, N.E.: The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines. Cancer Chemother. Pharmacol.201065, 1067-1081.
85. Gupta, D.; Yedidi, R.; Varghese, S.; Kovari, L.; Woster, P.M.: Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents. J. Med. Chem201053, 4234- 4247, DOI: 10.1021/jm100233b.
86. Lee, S.B.; Park, J.H.; Woster, P.M.; Casero, R.A.; Park, M.H.: Supression of exogenous gene expression by spermidine/spermine-N1-acetyltransferase 1 co-transfaction. J. Biol. Chem., 2010285, 15548-15556.
87. Sharma, S.K.; Wu, Y.; Steinbergs, N.; Crowley, M.L.; Hanson, A.S.; Casero, Jr., R.A.; Woster, P.M.: (Bis) urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators. J. Med. Chem201053, 5197-5212 (DOI: 10.1021/jm100217a).
88. Cervelli, M.; Bellavia, G.; Fratini, E., Amendola, R.; Polticelli, F.; Barba, M.; Federico, R.; Signore, F.; Gucciardo, G.; Grillo, R.; Woster, P.M.; Casero, R.A.; Mariottini, P.: Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm. BMC Cancer 201010, 555-564.
89. Woster, P.M.: Antiprotozoal/Antiparasitic Agents. In “Burger’s Medicinal Chemistry, Drug Discovery and Development – 7th Edition”, David P. Rotella and Donald J. Abraham, eds., John Wiley and Sons, Hoboken, NY, 2010, Vol. 7, pp 565-602.
90. Woster, P.M.: Chapter 15. Epigenetic Targets and Cancer Drug Discovery. Ann. Rep. Med. Chem.201045, 245-260.
91. Woster, P.M.: Use of polyamine derivatives as selective histone deacetylase inhibitors. Meth. Molec. Biol2011720, 475-491. 
92. Goodwin, A.C.; Destafano-Shields, C.E.; Wu, S.; Huso, D.L.; Wu, X.Q.; Murray-Stewart, T.R.; Hacker-Prietz, A.; Rabizadeh, S.; Woster, P.M.; Sears, C.; Casero, Jr., R.A.: Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc. Nat’l. Acad. Sci. U.S.A2011,108, 15354-15359.
93. Verlinden, B.; Niemand, J.; Sharma, S.K.; Beattie, R.J.; Woster, P.M.; Birkholtz, L.M.: Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities. J. Med. Chem201154, 6624-6633.
94. Zhu, Q.; Huang, Y.; Marton, L.J.; Woster, P.M.; Davidson, N.E.; Casero, Jr., R.A.: Polyamine analogues modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells. Amino Acids2011, epub ahead of print.
95. Fraser, A.V.; Goodwin, A.C.; Hacker-Prietz, A.; Sugar, E.; Woster, P.M.; Casero, Jr., R.A.: Knockdown of Ornithine Decarboxylase Antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells. Amino Acids,2011, epub ahead of print. 
96. Hanfrey, C.C.; Pearson, B.M.; Hazeldine, S.; Gaskin, D.J.; Lee, J.; Woster, P.M.; Phillips, M.A.; Michael, A.J.: An Alternative Spermidine Biosynthetic Route is Critical for Growth of Campylobacter jejuni and is the Dominant Polyamine Pathway in the Human Gut Microbiota. J. Biol. Chem., 2011286, 43301-43312. 
97. Silva, T.M.; Oredsson, S.; Persson, L.; Woster, P.M.; Marques, M.P.M.: Novel Pt(II) and Pd(II) Complexes with Polyamine Analogues: Synthesis and Vibrational Analysis. J. Inorganic Chem., 2012,108, 1-7.
98. Sharma, S.K.; Hazeldine, S.; Crowley, M.L.; Hanson, A.; Beattie, R.; Varghese, S.; Senanayake, T.M.D.; Hirata, A.; Hirata, F.; Wu, Y.; Steinbergs, N.; Murray-Stweart, T.; Bytheway, I.; Casero, R.A.; Woster, P.M.: Polyamine-based Small Molecule Epigenetic Modulators. Med. Chem. Comm2012, 3, 14-21. 
99. Schenk, T.; Howell, L.; Göllner, S.; Woster, P.M.; Marton, L.; Casero, R.A.; Dick, J.; Mills, K.; Burnett, A.; Müller-Tidow, C.; Petrie, K.; Zelent, A.: Inhibition of the LSD1/KDM1 histone demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nature Medicine201218, 605-611.
100. Yedidi, R.; Liu, Z.; Wang, Y.; Brunzelle, J.S.; Kovari, J.A.; Woster, P.M.; Kovari, L.C.; Gupta, D.: Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-     malarial compounds. Biochem. Biophys. Res. Comm. 2012421, 413-417.
101. Hazeldine, S.; Pachaiyappan, B.; Steinbergs, N.; Hanson, A.S.; Casero, Jr., R.A.; Woster, P.M.: Low molecular weight amidoximes that act as potent epigenetic modulators. J. Med. Chem., 2012, epub ahead of print.