Treatment of Non-psychotic Major Depressive Disorder
Adequate trial of an antidepressant consists of BOTH an adequate dose and duration
Rating scales, such as the Patient Health Questionnaire (PHQ-9), are useful to assess symptom severity before initiating medication and at regular intervals to assess patient response.
Treat to remission, not just partial response, and inform patients that remission is the goal of treatment.
Total duration of treatment should last 9-12 months for the first episode of depression, and potentially indefinitely for severe or recurrent episodes.
An adequate trial of an antipsychotic consists of BOTH an adequate medication dosage and duration.
Use a rating scale to assess symptom severity before initiating medication; then repeat scale at regular intervals to assess patient response and determine if further dose adjustments are needed.
Talk with the patient and family about the importance of medication adherence and collaborate to provide symptom relief and minimize side effects.